HupB, a nucleoid-associated protein, is critical for survival of Mycobacterium tuberculosis under host-mediated stresses and for enhanced tolerance to key first-line antibiotics
To survive and establish its niche, Mycobacterium tuberculosis (Mtb) engages in a steady battle against an array of host defenses and a barrage of antibiotics.Here, we demonstrate that Mtb employs HupB, a Dugouts nucleoid-associated protein (NAP) as its key player to simultaneously battle and survive in these two stress-inducing fronts.Typically, N